Pandemic influenza: Experts believe that the next influenza pandemic is imminent. With the recent H1N1 Mexican outbreak of "swine flu" and previous concerns about the current avian influenza strain H5N1 (and subclades) the threat is apparent.
This expert report provides a comprehensive up-to-date review of the current status of H5N1 pre-pandemic vaccines and investigates all of the critical issues with regard to their licensure, technology, safety and eventual use/deployment.
The report captures the viewpoints of 5 recognised global opinion leaders FDA VRBPAC and assesses the strengths/weaknesses of each commercial manufacturer's progress to date. An emphasis is placed on current expert perceptions with regard to adjuvantation, cell-based systems and the optimal immune response required to provide protection should a pandemic occur.
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