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MarketVIEW: Lassa fever virus vaccines

Published: January 2019

Lassa fever virus (LV) is an acute viral hemorrhagic illness caused by Lassa virus (LASV), a single-stranded RNA virus of the Arenaviridae family. The virus is zoonotic and mainly transmitted from the host, M natalensis (multimammate rate) to humans where it can cause symptoms ranging from fever, general malaise, weakness, and headache to the more serious outcomes of multi-organ failure or death. A significant cause of morbidity in survivors is deafness (which can be permanent) and occurs in approximately one-third of cases.

It is estimated that there are between 100,000 and 300,000 Lassa fever infections in West Africa per year, resulting in approximately 5,000 deaths, although estimates are outdated and impacted by a lack of routine surveillance. An epidemic continues to increase in certain parts of Nigeria. Intravenous ribavirin (if given early) can reduce mortality. There are a number or prophylatic Lassa fever vaccines in pre-clinical development supported by CEPI/WHO initiatives but none yet in clinical stages.

This MarketVIEW product is a comprehensive Executive Presentation (~100 slides) and MS-Excel forecast model which investigates the commercial potential of a putative Lassa fever vaccine in all relevant target groups (preventative and emergency scenarios). There is a detailed case study analysis of Ebola vaccine procurement/deployment to serve as guidance with all assumptions clearly outlined. A thorough review of current disease background/epidemiology and R&D competitive environment are also included.


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